33/73
  • Pages
  • Editions
01 Cover
02 Welcome Letter / Sections
03 Article & Interview Directory
04 Section 1: Introduction
05 Introduction to US Life Sciences
06 Janssen Pharmaceuticals Interview
07 Investment Climate
08 MPM Capital Interview
09 Signet Healthcare Partners Interview
10 Xontogeny Interview
11 Insights from EisnerAmper
12 The Life Sciences Regulatory Climate
13 Buchanan Ingersoll & Rooney PC Interview
14 PhRMA Interview
15 PBOA Interview
16 Ernst & Young LLP Interview
17 LaVoieHealthScience Interview
18 Section 2: Introducing the Hubs
19 East Coast
20 BioNJ Interview
21 MassBio Interview
22 Pennsylvania Biotechnology Center Interview
23 West Coast
24 Biocom California Interview
25 QB3-Berkeley Interview
26 Section 3: Drug Discovery and Development
27 Therapeutic Fields On Fire
28 Insmed Interview
29 Mammoth Biosciences Interview
30 Innovations Enhancing the Patient Experience
31 Arcturus Therapeutics Interview
32 Karius Interview
33 Expert Insights: Targeted Therapeutics
34 First Wave BioPharma Interview
35 Aphios Corporation Interview
36 Section 4: Contract Manufacturing and Chemicals
37 A Shifting Landscape
38 Syngene International Interview
39 Cambrex Interview
40 Lubrizol Life Science Interview
41 Aenova Group Interview
42 Keeping Up With Demands
43 Cureline Interview
44 Interview: Murli Krishna Pharma
45 PsychoGenics Interview
46 Expert Insights: Innovative Technologies
47 AMPAC Fine Chemicals Interview
48 TCG Lifesciences Interview
49 CordenPharma Interview
50 Quotient Sciences Interview
51 A Post-Pandemic World
52 New Vision Pharmaceuticals Interview
53 Adare Pharma Solutions Interview
54 Ascendia Pharmaceuticals Interview
55 Chemicals Producers and Distributors
56 Brenntag North America Interview
57 BASF Pharma Solutions Interview
58 Section 5: Technology Services
59 Life Sciences Go Digital
60 RxS Interview
61 Insights from Markem-Imaje
62 AiCure Interview
63 WhizAI Interview
64 Section 6: Company Profiles
65 Brenntag Company Profile
66 Adare Pharma Solutions Company Profile
67 Quotient Sciences Company Profile
68 SK pharmteco Company Profile
69 AiCure Company Profile
70 Markem-Imaje Company Profile
71 TCG Lifesciences Company Profile
72 Murli Krishna Pharma Company Profile
73 Credits

Expert Insights: Targeted Therapeutics


From the eye to the gut, the following companies are advancing the standard of care for several different therapeutic areas.

“Outlook Therapeutics hopes to bring to market an investigational ophthalmic version of bevacizumab, a molecule that has been used to treat retinal disorders for several years but has never received approval from major regulatory agencies to be used as an ophthalmic drug solution. If our ophthalmic bevacizumab is approved, we will potentially enhance the standard of care for patients with disorders like wet AMD, diabetic macular edema, and branch retinal vein occlusion by removing concerns related to off-label repackaged IV product. We firmly believe that if a substance is to be injected into a patient's eye, it should meet the various requirements necessary to earn FDA approval for ophthalmic use.”

Russell Trenary, President & CEO, Outlook Therapeutics

“Our mission is to bring novel and transformative therapies to the anterior (front) chamber of the eye, particularly for the treatment of ocular surface disease. The company obtained its first FDA approval in 2021 for its Tyrvaya medication, the first and only nasal spray for the treatment of the signs and symptoms of dry eye disease.”

Jeffrey Nau, President & CEO, Oyster Point Pharma

“The company’s second pillar, brensocatib, is currently in a phase 3 clinical trial as the first investigational DPP1 inhibitor developed for neutrophil-driven inflammatory conditions… The drug is unique in that it targets the inflammatory process associated with bronchiectasis rather than the historically unsuccessful approach of treating with anti-infectives. Results from the phase 2 trial were published in the New England Journal of Medicine, the first time in nearly 20 years this journal has published on bronchiectasis.”

Will Lewis, Chairman & CEO, Insmed

“We are developing product candidates of standardized composition based on defined bacterial strains grown from clonal cell banks in a manner analogous to monoclonal antibody production… We believe that our targeted approach could offer consistent composition and quality attributes, provide more consistent clinical benefit, limit safety risk, and enable greater scalability compared with fecal-derived approaches.”

Bernat Olle, CEO, Vedanta Biosciences

“During the pandemic AzurRx BioPharma decided to acquire First Wave Bio, and the merged company was renamed First Wave BioPharma. Through the transaction and merger, we purchased full rights to First Wave’s proprietary formulations of niclosamide and exclusive international rights to develop oral and topical formulations of the compound for all gastrointestinal indications including Covid-related GI infections, IBD indications including ulcerative colitis (UC) and Crohn’s disease, and immune checkpoint inhibitor-associated colitis and diarrhea. We own the method of usage and delivery of these formulations as therapies for several auto-immune, inflammatory and viral ailments.”

James Sapirstein, Chairman, President and CEO, First Wave BioPharma

Image courtesy of CDC on Unsplash

Next:

Interview: First Wave BioPharma